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In the past I was using Cydectin at freshening, but recently I saw that it has a 56 day milk withdrawl time.....that's a looooong time! Am I better off using something else? What do y'all use at freshening? I used Ivermectin plus this week on all my does who are due in the next month. Should I use it again in 10 days? I'm in Texas & of course our weather has been crazy!
 
G

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Pam.....where did you see thay cydectin had a 56 dat WDT ?

I had it as being none, but I usually wait about a week anyway.

Whim
 

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What you are seeing is Moxidectin- Quest -extra lable 0.5mg/kg PO 23 days meat 56 days milk.

Well......Quest is 4x's stronger than Cydectin pour-on. It's the horse version of moxidectin. According to *that* list the pour-on is not even listed. ?? Nor is there a date it was released. So, I'm going to stick my neck out here and say if you use Quest at 1cc/22#'s...yes, you will have a long withdrawl rate. Reason I posted the dose for Quest in goats 101.

The lable says: Moxidectin

RESIDUE WARNING

When used according to label directions, neither a pre-slaughter drug withdrawal period nor a milk discard time are required. Meat and milk from cattle treated with CYDECTIN (moxidectin) Pour-On may be used for human consumption at any time following treatment. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

LOL...Dipyrone hasn't even been manufactured in at least 10 yrs., so that tells you how up to date that info. is.

It took me some debating with myself to even post this info. :/
Kaye
 

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The zero withdrawal listed on Cydectin is using it per label -as a pour-on for cattle. The FARAD chart also lists it as 56 days. I questioned my vet about this last year and he said the reason is because of the off label use - so they go with the extended w/d. His 'opinion' was that I should go at least 30 days but of course there is no data to support this either.
 

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Extralabel Use of Moxidectin:

Oral route-Moxidectin is not approved for use in goats. Several goat farmers have been administering moxidectin to goats orally at the labeled pour-on dose (0.5 mg/kg) for cattle. It should be stressed that although the cattle label states that this drug has a zero meat and milk WDT by the topical route, it does not imply that the meat and milk WDI will be zero if given orally. Until FARAD obtains sufficient pharmacokinetic data for the topical formulation given orally at 0.5 mg/kg in goats, FARAD has based its WDI recommendation on European Union approvals in sheep and published studies on oral administration. It should be noted that oral bioavailability of moxidectin is 2.7 times lower in goats than in sheep,6,14 and the half-life in goats is 1.8 times shorter in sheep. This suggests that EU WDI for moxidectin in sheep will be more than adequate for estimation of WDI for moxidectin drench in goats. In France and the United Kingdom, the oral formulation for sheep at a dose of 0.2 mg/kg [0.09 mg/lb] has a 14-day meat WDT.15,16 On the basis of these data, FARAD estimates an ERH of 3 days for this dose and, therefore, includes an additional 3 ERH (9 days; WDI, 23 days) for goats given of a moxidectin pour-on formulation (0.8 to 1.6 mg/kg [0.36 to 0.73 mg/lb]) orally. It must be recognized that there are pharmaceutical differences between the dermal formulations being used in goats and the European approved drench, and these differences may influence tissue depletion. It is also important to stress that, irrespective of the route of administration, moxidectin has a longer mean residence time than ivermectin in sheep and in cattle when given orally or by the SC route.7,14,17 This may be related to its greater persistence once absorbed systemically and, therefore, caution should be exercised when using this drug in an extralabel manner, especially when administering the pour-on formulation orally to goats.

Topical route-Moxidectin is approved as a pour-on only (0.5mg/kg) in cattle with zero meat and milk WDT, and it is possible that increasing the dose substantially by this route will most likely require estimation of meat and milk WDI (Table 1). In the absence of data for goats, FARAD assumes that plasma and tissue clearance would be greater in goats than in cattle, as described for ivermectin. However, FARAD would err on the side of caution and recommend a milk and meat WDI of 1 day if this drug was topically applied to goats.
DRUG SPECIES ROUTE DOSE (mg/kg) Meat WDI (days) Milk WDI (days)
IVERMECTIN Goats Oral 0.2 11 6
Goats Oral 0.2 -0.4 14 9
Cows Oral 0.2 *24 28
Goats SQ 0.2 35 40
Cows SQ 0.2 *35 47
Goats Topical 0.4 NA 7
Cows Topical 0.4 *48 53

MOXIDECTIN Goats Oral 0.2 14 NA
Goats Oral 0.5 23 NA
Cows Oral 0.2 NA NA
Goats SQ 0.2 NA NA
Cows SQ 0.2 49 NA
Goats Topical 0.5 1 1
Cows Topical 0.5 *0 *0
NA=not available; *=FDA approved WDT

References:
1. Martin T, Baynes RE, Craigmill AL, et al. Pharm Res 2000
2. Escudero E, Carceles CM, Diaz MS, et al. Pharmacokinetics of moxidectin and doramectin in goats. Res Vet Sci 1999;67: 177-181.
3. Scott EW, Kinabo LD, McKellar QA. Pharmacokinetics of ivermectin after oral or percutaneous administration to adult milking goats. J Vet Pharmacol Therap 1990;13: 432-435
4. NRSP-7 Animal Drug Request Number
5. NRSP-7 Studies of Ivermectin in Goats (SQ Administration). Public Master File (PMF 3883)
6. FAO. Moxidectin: Residues of some veterinary drugs in animals and foods. Monographs prepared by the forty-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives, Geneva, Switzerland, February 1997.
7. EMEA. Moxidectin Summary Report. European Agency for the Evaluation of Medicinal Products, 1999;London, UK.
8. FOI (1998). Freedom of Information Summary, NADA 141-099 (original); Cydectin (moxidectin); January 28th, 1998.
 

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Considering I have seen two actual tests done on goats given Cydectin orally...that came back with hours, not days of withdrawal, I would highly doubt this information as fact. Fact as in the goats were given the drug, the milk was tested for residue. Also remember this doesn't have to be the drug in the milk, it can be the carrier, like that what is found in Ivermectins. If you look at some of the other withdrawals, couple that with the information this is for a meat goat continuing education, meat goat facilities funding this, drugs on there we can't get any longer...I highly doubt this has any benefit to dairy goats. I would like to see the published tests themselves, they would have to prove they even did one milk test, and not just extrapolated out from the meat withdrawal what the milk withdrawal is. I am not the only one who knows how hard it is to get anything to penetrate into the udder to work for mastitis, let alone a wormer that will even show up in the milk for a month and a half.

Such a shame the caliber of Nubian Talk is such now..... that we could just post to the major breeders who used to frequent that site for their ideas on this...sadly it would be a bunch of new folks with......well, anyway that certainly wouldn't be helpful ;)

Doubting Vicki
 

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I am not the only one who knows how hard it is to get anything to penetrate into the udder to work for mastitis, let alone a wormer that will even show up in the milk for a month and a half.
BOY, IS THAT THE HONEST TRUTH!!
Such a shame the caliber of Nubian Talk is such now.....
Vicki, it's not just Nubian Talk it's ANYWHERE. You try to post information, that has research DONE ON DAIRY GOATS or try to give information on drugs and it just ignites a debate with loads of misinformation. What's so sad is the people actually *know* refuse to be drawn into these debates and the correct information is never shared. I for one, refuse to argue a point. I tell you what I think, when you ask, then I leave it up to you to use it or keep searching the internet until you find what you want to hear.

Maybe when/if the internet crashes....people will learn like we did in years past. TRIAL & ERROR and depend on those that have actually done the research.

:soap
Kaye
 

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Well all I can say is that since Cydectin came out I have been using it and wait a full 24 hrs and use the milk am still here and so are my customers.
 
G

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:biggrin Well maybe you needed a little worming out yourself Sondra. I bet a little exlax and cydectin in a cocktail would move a whole lot of stuffffff.
 
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