I have 2-18 mos. does I will be giving this to tonite....5 cc sub-q. do you have to place it where the cd&t is done? Is there a reaction? I know these guys have not had it before...no vaccines at all. With this order I got byomicin, does that need to be refrigerated as do the vaccines? I do have a 3 year old, not sure if she has had this, do I go ahead and give it to her too? Thanks..