Nothing is "safe" to use in the first 40-45 days of pregnancy. We prefer to wait until after these days for safety of the fetus. In a life and death situation...then the does life comes first. And yes, I have used it in such a case. Gentomycin does not cause the side effects in goats that it does in other species. Bone degeneration, teeth discoloration,ect... BUT...this warning goes along with it: Do not use in food producing animals. CAUTION : GENTAMICIN SHOULD NEVER BE USED IN FOOD PRODUCING ANIMALS OR ANIMALS INTENDED FOR FOOD (residues can be detected in kidney tissues for up to 18 months). Kaye